GHK-Cu(Copper Peptide) Stimulates of Hair Growth
|| The top photo is skin untreated with copper-peptides.
The bottom photo is skin treated with copper-peptides. with the following observation:
the larger hair follicles (the elongated purple columns)
the increased content of subcutaneous fat in the skin
the increased thickness of the skin.
Hair researchers have noted the accumulation of this fat around healthy follicles that are vigorously growing hair, and its relative lack around dormant follicles, have postulated that these cells serve a supportive function for the hair follicle.
The administration of copper-peptides increases hair follicle size and the rate of hair growth caused due to it's causing blood flow changes that provide adequate nutrients to the follicle, producing faster growing hair with thicker hair shafts. Copper ion complexed with certain peptides has both skin repair and hair growth enhancement effects.
1. Hair follicle before remodeling signaled by GHK-Cu(Copper Peptide).
2. The remodeling signal by GHK-Cu(Copper Peptide) increases the size of the hair follicles.
3. The enlarged hair follicle begins to produce new skin cells that migrate into the surrounding skin and rebuild the skin after usw of GHK-Cu(Copper Peptide).
GHK-Cu(Copper Peptide) induce a proliferation of hair follicles
|| The photograph on the top is a microscopic field of hair follicles treated only with saline.
The photograph on the bottom is a similar area of skin treated with copper-peptides and which has a much higher density of hair follicles.
Minoxidil, GHK-Cu, Thymosin b4, Procyanidin B2, Adenosine,
Vitamin Complex (Vitamins A, C, and E in nanosomes), Lactic Acid, Propylene Glycol,
Ethanol, DI Water
Copper Peptide Improve Hair Growth Studies:
| Study|| Result|| Reference|
| Use of GHK-Cu analogs for hair follicle enlargement and stimulation of hair growth|| Methods for the design and testing of copper-peptide complexes with hair growth properties are described.|
A wide variety of GHK-Cu analogs were described that increase hair follicle size and increase hair growth in mice and rats.
| US Patent 5,120,831 New metal peptide complexes and derivatives used for stimulating growth of hair in warm-blooded animals, especially humans. Pickart US Patent 5,177,061 Compositions for stimulating hair growth containing cupric complexes of peptide derivatives including. glycyl-l-histidyl-l-lysine n-octyl ester. Pickart US Patent 5,214,032 New glycyl-histidyl-lysyl copper compounds used in stimulating hair growth. Pickart US 5,550,183 Metal-peptide compositions and methods for stimulating hair growth. Pickart |
| Human hair growth|| Stimulation of hair growth in humans with GHK-Cu analogs|| Phototrichogram Analysis of Hair Follicle Stimulation: A pilot clinical study with a peptide-copper complex. Patt, Duncan and Kalis (University of Reims, France) Dermatological Research Techniques, (CRC Press), pp-217-226, 1996|
| Human study of hair growth with GHK-Cu analog|| Compared GHK-CU analog in Tricomin with 2% minoxidil. Tricomin 2.5% increased hair count by 97 non-vellus hairs while 2% minoxidil increased count by 73 non-vellus hair after 3 months (non-vellus hair count)|| Procyte Corp. press release 1997|
| Breakdown resistant, long acting copper-peptides used for stimulation of hair growth|| Tested copper complexed with protein peptones for hair growth effects in mice. Copper-peptide mixture produced more hair growth in mice than GHK-Cu analogs|| Pickart US Patent 5,554,375 Tissue protective and regenerative compositions. |